{"id":10502,"date":"2024-10-30T10:07:30","date_gmt":"2024-10-30T10:07:30","guid":{"rendered":"https:\/\/www.tcm-vet.com\/?p=10502"},"modified":"2024-10-30T10:07:38","modified_gmt":"2024-10-30T10:07:38","slug":"%e7%b4%94%e8%a1%80%e7%8a%ac%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e7%99%8c%e3%81%ae%e9%81%ba%e4%bc%9d%e7%9a%84%e7%b4%a0%e5%9b%a0","status":"publish","type":"post","link":"https:\/\/www.tcm-vet.com\/ja\/genetic-predisposition-to-cancer-in-purebred-dogs\/","title":{"rendered":"\u7d14\u8840\u72ac\u306b\u304a\u3051\u308b\u764c\u306e\u907a\u4f1d\u7684\u7d20\u56e0"},"content":{"rendered":"

\u764c\u306f\u72ac\u306b\u304a\u3051\u308b\u6700\u3082\u4e00\u822c\u7684\u306a\u5065\u5eb7\u554f\u984c\u306e\u4e00\u3064\u3067\u3042\u308a\u3001\u3059\u3079\u3066\u306e\u72ac\u7a2e\u3084\u96d1\u7a2e\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u7814\u7a76\u306b\u3088\u308b\u3068\u3001\u7279\u5b9a\u306e\u7d14\u8840\u72ac\u306f\u7279\u5b9a\u306e\u764c\u306b\u5bfe\u3059\u308b\u611f\u53d7\u6027\u304c\u9ad8\u304f\u3001\u907a\u4f1d\u5b66\u304c\u764c\u30ea\u30b9\u30af\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u8a18\u4e8b\u3067\u306f\u3001\u72ac\u306b\u304a\u3051\u308b\u72ac\u7a2e\u7279\u6709\u306e\u907a\u4f1d\u7684\u8981\u56e0\u3068\u764c\u306e\u7a2e\u985e\u3068\u306e\u95a2\u9023\u3092\u63a2\u308a\u3001\u764c\u306e\u539f\u56e0\u3084\u5c06\u6765\u306e\u6cbb\u7642\u306b\u95a2\u3059\u308b\u65b0\u305f\u306a\u6d1e\u5bdf\u3092\u63d0\u4f9b\u3059\u308b\u907a\u4f1d\u7814\u7a76\u306e\u6700\u8fd1\u306e\u9032\u5c55\u306b\u7126\u70b9\u3092\u5f53\u3066\u3066\u3044\u307e\u3059\u3002.<\/p>\n\n\n\n

\u7d14\u8840\u72ac\u306b\u304a\u3051\u308b\u764c\u611f\u53d7\u6027\u306b\u304a\u3051\u308b\u907a\u4f1d\u306e\u5f79\u5272<\/h3>\n\n\n\n

\u7d14\u8840\u72ac\u306f\u3001\u72ac\u7a2e\u306e\u7cfb\u7d71\u5185\u3067\u306e\u907a\u4f1d\u7684\u591a\u69d8\u6027\u304c\u9650\u3089\u308c\u3066\u3044\u308b\u305f\u3081\u3001\u7279\u5b9a\u306e\u764c\u306b\u5bfe\u3057\u3066\u3088\u308a\u9ad8\u3044\u30ea\u30b9\u30af\u3092\u62b1\u3048\u308b\u3053\u3068\u304c\u3088\u304f\u3042\u308a\u307e\u3059\u3002\u4e16\u4ee3\u3092\u8d85\u3048\u305f\u9078\u629e\u7684\u7e41\u6b96\u306f\u3001\u5404\u72ac\u7a2e\u5185\u306b\u72ec\u81ea\u306e\u907a\u4f1d\u7684\u30d1\u30bf\u30fc\u30f3\u3092\u3082\u305f\u3089\u3057\u3001\u305d\u306e\u4e2d\u306b\u306f\u764c\u306e\u7d20\u56e0\u907a\u4f1d\u5b50\u3092\u6301\u3064\u3082\u306e\u3082\u3042\u308a\u307e\u3059\u3002\u4eba\u9593\u306e\u5e83\u7bc4\u306a\u907a\u4f1d\u7684\u591a\u69d8\u6027\u3068\u306f\u7570\u306a\u308a\u3001\u7d14\u8840\u72ac\u306e\u72ed\u307e\u3063\u305f\u907a\u4f1d\u5b50\u30d7\u30fc\u30eb\u306f\u907a\u4f1d\u7814\u7a76\u3092\u3088\u308a\u7ba1\u7406\u3057\u3084\u3059\u304f\u3057\u3001\u3088\u308a\u5c0f\u3055\u306a\u96c6\u56e3\u306b\u5bfe\u3059\u308b\u30bf\u30fc\u30b2\u30c3\u30c8\u3092\u7d5e\u3063\u305f\u7814\u7a76\u3092\u53ef\u80fd\u306b\u3057\u307e\u3059\u3002.<\/p>\n\n\n\n

\u4e00\u822c\u7684\u306a\u764c\u306e\u7a2e\u985e\u3068\u30ea\u30b9\u30af\u306e\u3042\u308b\u72ac\u7a2e<\/h3>\n\n\n\n
    \n
  1. \u30d2\u30b9\u30c8\u30ea\u30aa\u30b5\u30a4\u30c8\u30fc\u30de<\/strong>
    \u30d0\u30fc\u30cb\u30fc\u30ba\u30fb\u30de\u30a6\u30f3\u30c6\u30f3\u30fb\u30c9\u30c3\u30b0\u3084\u30d5\u30e9\u30c3\u30c8\u30b3\u30fc\u30c6\u30c3\u30c9\u30fb\u30ec\u30c8\u30ea\u30fc\u30d0\u30fc\u306a\u3069\u306e\u72ac\u7a2e\u306b\u4e3b\u306b\u898b\u3089\u308c\u308b\u30d2\u30b9\u30c8\u30ea\u30aa\u30b5\u30a4\u30c8\u30fc\u30de\u306f\u3001\u514d\u75ab\u7d30\u80de\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u653b\u6483\u7684\u306a\u764c\u3067\u3059\u3002\u3053\u308c\u3089\u306e\u72ac\u7a2e\u306b\u95a2\u3059\u308b\u907a\u4f1d\u7684\u7814\u7a76\u306f\u3001\u65e9\u671f\u8a3a\u65ad\u3084\u5c06\u6765\u306e\u7814\u7a76\u306b\u5f79\u7acb\u3064\u53ef\u80fd\u6027\u306e\u3042\u308b\u907a\u4f1d\u7684\u95a2\u9023\u3092\u660e\u3089\u304b\u306b\u3057\u3066\u3044\u307e\u3059\u3002.<\/li>\n\n\n\n
  2. \u9aa8\u8089\u816b<\/strong>
    \u30b0\u30ec\u30fc\u30c8\u30fb\u30c7\u30fc\u30f3\u3001\u30b0\u30ec\u30a4\u30cf\u30a6\u30f3\u30c9\u3001\u30ed\u30c3\u30c8\u30ef\u30a4\u30e9\u30fc\u306a\u3069\u306e\u5927\u578b\u72ac\u7a2e\u3084\u5de8\u5927\u72ac\u7a2e\u306f\u3001\u75db\u307f\u3092\u4f34\u3046\u9aa8\u306e\u764c\u3067\u3042\u308b\u9aa8\u8089\u816b\u306b\u5bfe\u3057\u3066\u3088\u308a\u611f\u53d7\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u907a\u4f1d\u7684\u5206\u6790\u306b\u3088\u308a\u3001\u9aa8\u8089\u816b\u30ea\u30b9\u30af\u3092\u4e88\u6e2c\u3059\u308b\u53ef\u80fd\u6027\u306e\u3042\u308b\u30de\u30fc\u30ab\u30fc\u304c\u7279\u5b9a\u3055\u308c\u3001\u65e9\u671f\u767a\u898b\u3084\u6539\u5584\u3055\u308c\u305f\u6cbb\u7642\u30a2\u30d7\u30ed\u30fc\u30c1\u306b\u5bc4\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002.<\/li>\n\n\n\n
  3. \u8840\u7ba1\u8089\u816b<\/strong>
    \u30d8\u30de\u30f3\u30ae\u30aa\u30b5\u30eb\u30b3\u30fc\u30de\u306f\u3001\u30b4\u30fc\u30eb\u30c7\u30f3\u30ec\u30c8\u30ea\u30fc\u30d0\u30fc\u3001\u30c9\u30a4\u30c4\u30b7\u30a7\u30d1\u30fc\u30c9\u3001\u30e9\u30d6\u30e9\u30c9\u30fc\u30eb\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u304a\u308a\u3001\u8840\u7ba1\u58c1\u306b\u8d77\u6e90\u3092\u6301\u3064\u6025\u901f\u306b\u6210\u9577\u3059\u308b\u764c\u3067\u3059\u3002\u5168\u30b2\u30ce\u30e0\u95a2\u9023\u89e3\u6790\uff08GWAS\uff09\u304c\u30d8\u30de\u30f3\u30ae\u30aa\u30b5\u30eb\u30b3\u30fc\u30de\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u7684\u7279\u6027\u3092\u660e\u3089\u304b\u306b\u3057\u3001\u305d\u306e\u907a\u4f1d\u7684\u57fa\u76e4\u306e\u3088\u308a\u660e\u78ba\u306a\u7406\u89e3\u3092\u63d0\u4f9b\u3057\u59cb\u3081\u3066\u3044\u307e\u3059\u3002.<\/li>\n\n\n\n
  4. \u30de\u30b9\u30c8\u7d30\u80de\u816b<\/strong>
    \u30de\u30b9\u30c8\u7d30\u80de\u816b\u306f\u3001\u30dc\u30af\u30b5\u30fc\u3001\u30d6\u30eb\u30c9\u30c3\u30b0\u3001\u30dc\u30b9\u30c8\u30f3\u30c6\u30ea\u30a2\u306a\u3069\u306e\u72ac\u7a2e\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002\u907a\u4f1d\u7684\u7814\u7a76\u306f\u3001\u3053\u308c\u3089\u306e\u72ac\u7a2e\u306b\u304a\u3051\u308b\u7279\u5b9a\u306eDNA\u5909\u7570\u304c\u3053\u306e\u764c\u306b\u5bfe\u3059\u308b\u7d20\u56e0\u3092\u6301\u3064\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u304a\u308a\u3001\u30de\u30b9\u30c8\u7d30\u80de\u816b\u306e\u767a\u751f\u3092\u7406\u89e3\u3059\u308b\u305f\u3081\u306e\u65b0\u305f\u306a\u9053\u3092\u63d0\u4f9b\u3057\u3066\u3044\u307e\u3059\u3002.<\/li>\n\n\n\n
  5. \u30ea\u30f3\u30d1\u816b<\/strong>
    \u30dc\u30af\u30b5\u30fc\u3084\u30e9\u30d6\u30e9\u30c9\u30fc\u30eb\u30ec\u30c8\u30ea\u30fc\u30d0\u30fc\u306a\u3069\u306e\u72ac\u7a2e\u306f\u3001\u30ea\u30f3\u30d1\u816b\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u3063\u3066\u3044\u307e\u3059\u3002\u6700\u8fd1\u306e\u5206\u5b50\u907a\u4f1d\u5b66\u7684\u7814\u7a76\u306f\u3001\u3053\u308c\u3089\u306e\u72ac\u306b\u304a\u3051\u308b\u30ea\u30f3\u30d1\u816b\u306b\u95a2\u9023\u3059\u308b\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u3092\u5f37\u8abf\u3057\u3066\u304a\u308a\u3001\u4e88\u9632\u304a\u3088\u3073\u8a3a\u65ad\u30c4\u30fc\u30eb\u306e\u4f5c\u6210\u3092\u652f\u63f4\u3057\u3066\u3044\u307e\u3059\u3002.<\/li>\n\n\n\n
  6. \u30e1\u30e9\u30ce\u30fc\u30de<\/strong>
    \u30e1\u30e9\u30ce\u30fc\u30de\u306f\u3001\u30b7\u30e5\u30ca\u30a6\u30b6\u30fc\u3084\u30b9\u30b3\u30c6\u30a3\u30c3\u30b7\u30e5\u30c6\u30ea\u30a2\u306a\u3069\u306e\u72ac\u7a2e\u3067\u4e00\u822c\u7684\u306b\u898b\u3089\u308c\u3001\u76ae\u819a\u306e\u8272\u7d20\u7d30\u80de\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u307e\u3059\u3002\u7d30\u80de\u907a\u4f1d\u5b66\u7684\u7814\u7a76\u306f\u3001\u3053\u308c\u3089\u306e\u72ac\u7a2e\u306b\u304a\u3051\u308b\u907a\u4f1d\u7684\u5909\u5316\u3092\u7279\u5b9a\u3057\u3066\u304a\u308a\u3001\u30e1\u30e9\u30ce\u30fc\u30de\u306e\u767a\u751f\u3068\u9032\u884c\u3092\u4e88\u6e2c\u3059\u308b\u306e\u306b\u5f79\u7acb\u3064\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002.<\/li>\n\n\n\n
  7. \u4e73\u817a\u816b\u760d<\/strong>
    \u30d7\u30fc\u30c9\u30eb\u3084\u30b3\u30c3\u30ab\u30fc\u30b9\u30d1\u30cb\u30a8\u30eb\u306a\u3069\u306e\u5c0f\u578b\u72ac\u7a2e\u306f\u3001\u4e73\u817a\u816b\u760d\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3067\u3059\u3002\u907a\u4f1d\u5b50\u30de\u30c3\u30d4\u30f3\u30b0\u306f\u3001\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u5909\u7570\u304c\u3053\u308c\u3089\u306e\u816b\u760d\u306b\u5bfe\u3059\u308b\u611f\u53d7\u6027\u3092\u9ad8\u3081\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u304a\u308a\u3001\u3088\u308a\u826f\u3044\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u306e\u9053\u3092\u958b\u3044\u3066\u3044\u307e\u3059\u3002.<\/li>\n<\/ol>\n\n\n\n

    \u6700\u8fd1\u306e\u9032\u5c55\uff1a\u72ac\u306b\u304a\u3051\u308b\u5168\u30b2\u30ce\u30e0\u95a2\u9023\u89e3\u6790<\/h3>\n\n\n\n

    \u6700\u8fd1\u306e\u6280\u8853\u7684\u9032\u6b69\u306b\u3088\u308a\u3001\u7814\u7a76\u8005\u306f\u72ac\u7a2e\u306b\u5bfe\u3057\u3066\u5168\u30b2\u30ce\u30e0\u95a2\u9023\u89e3\u6790\uff08GWAS\uff09\u3092\u5b9f\u65bd\u3057\u3001\u764c\u95a2\u9023\u306e\u907a\u4f1d\u7684\u30de\u30fc\u30ab\u30fc\u3092\u7cbe\u5bc6\u306b\u7279\u5b9a\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u7814\u7a76\u306f\u3001\u7279\u5b9a\u306e\u764c\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u7684\u5909\u7570\u3092\u7279\u5b9a\u3057\u3001\u65e9\u671f\u8a3a\u65ad\u3001\u4e88\u9632\u7b56\u3001\u304a\u3088\u3073\u500b\u5225\u5316\u3055\u308c\u305f\u6cbb\u7642\u3092\u53ef\u80fd\u306b\u3057\u307e\u3059\u3002\u57fa\u790e\u3068\u306a\u308b\u907a\u4f1d\u7684\u8981\u7d20\u3092\u7406\u89e3\u3059\u308b\u3053\u3068\u3067\u3001\u7363\u533b\u5e2b\u3084\u30d6\u30ea\u30fc\u30c0\u30fc\u306f\u3001\u7d20\u56e0\u306e\u3042\u308b\u72ac\u7a2e\u306b\u304a\u3051\u308b\u764c\u30ea\u30b9\u30af\u3092\u8efd\u6e1b\u3059\u308b\u305f\u3081\u306e\u60c5\u5831\u306b\u57fa\u3065\u3044\u305f\u6c7a\u5b9a\u3092\u4e0b\u3059\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002.<\/p>\n\n\n\n

    \u7363\u533b\u816b\u760d\u5b66\u3068\u72ac\u306e\u5065\u5eb7\u3078\u306e\u5f71\u97ff<\/h3>\n\n\n\n

    \u72ac\u7a2e\u7279\u6709\u306e\u907a\u4f1d\u7684\u7814\u7a76\u304c\u9032\u3080\u306b\u3064\u308c\u3066\u3001\u30da\u30c3\u30c8\u306e\u98fc\u3044\u4e3b\u3084\u7363\u533b\u5e2b\u306f\u72ac\u306e\u764c\u30ea\u30b9\u30af\u3092\u7406\u89e3\u3057\u7ba1\u7406\u3059\u308b\u305f\u3081\u306e\u3088\u308a\u591a\u304f\u306e\u30ea\u30bd\u30fc\u30b9\u3092\u6301\u3064\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002\u72ac\u306e\u907a\u4f1d\u7684\u7d20\u56e0\u3092\u77e5\u308b\u3053\u3068\u3067\u3001\u65e9\u671f\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3001\u4e88\u9632\u7b56\u3001\u8fc5\u901f\u306a\u4ecb\u5165\u304c\u53ef\u80fd\u306b\u306a\u308a\u3001\u6700\u7d42\u7684\u306b\u306f\u30ea\u30b9\u30af\u306e\u3042\u308b\u72ac\u7a2e\u306e\u751f\u6d3b\u306e\u8cea\u304c\u5411\u4e0a\u3057\u307e\u3059\u3002\u3053\u306e\u7814\u7a76\u306f\u3001\u72ac\u304c\u6bd4\u8f03\u816b\u760d\u5b66\u306b\u304a\u3051\u308b\u8cb4\u91cd\u306a\u30e2\u30c7\u30eb\u3068\u3057\u3066\u306e\u5f79\u5272\u3092\u5f37\u5316\u3057\u3001\u72ac\u3068\u4eba\u9593\u306e\u764c\u6cbb\u7642\u306e\u9032\u5c55\u306b\u5bc4\u4e0e\u3057\u307e\u3059\u3002.<\/p>\n\n\n\n

    \u72ac\u306e\u764c\u4e88\u9632\u306e\u305f\u3081\u306e\u907a\u4f1d\u7684\u6d1e\u5bdf\u306e\u6d3b\u7528<\/h3>\n\n\n\n

    \u7279\u5b9a\u306e\u72ac\u7a2e\u306b\u304a\u3051\u308b\u764c\u306b\u5bfe\u3059\u308b\u907a\u4f1d\u7684\u7d20\u56e0\u306f\u3001\u7363\u533b\u816b\u760d\u5b66\u306b\u304a\u3051\u308b\u907a\u4f1d\u7684\u7814\u7a76\u306e\u91cd\u8981\u6027\u3092\u5f37\u8abf\u3057\u3066\u3044\u307e\u3059\u3002\u9032\u884c\u4e2d\u306e\u907a\u4f1d\u7684\u767a\u898b\u306b\u3088\u308a\u3001\u7279\u5b9a\u306e\u764c\u306b\u5bfe\u3057\u3066\u30ea\u30b9\u30af\u306e\u9ad8\u3044\u72ac\u7a2e\u306f\u3001\u3088\u308a\u500b\u5225\u5316\u3055\u308c\u305f\u533b\u7642\u6226\u7565\u306e\u6069\u6075\u3092\u53d7\u3051\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u3053\u306e\u7814\u7a76\u306f\u3001\u72ac\u306e\u5065\u5eb7\u3092\u6539\u5584\u3059\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u7a2e\u3092\u8d85\u3048\u305f\u764c\u907a\u4f1d\u5b66\u306e\u7406\u89e3\u3092\u6df1\u3081\u308b\u3053\u3068\u306b\u3082\u5bc4\u4e0e\u3057\u307e\u3059\u3002.<\/p>","protected":false},"excerpt":{"rendered":"

    Cancer remains one of the most common health issues in dogs, affecting all breeds and crossbreeds. However, studies show that certain purebred dogs have a heightened susceptibility to specific cancers, suggesting that genetics may play a significant role in cancer risk. This article explores the connection between breed-specific genetic factors and cancer types in dogs, focusing on recent advances in genetic research that offer new insights into the causes of cancer and potential future treatments. The Role of Genetics in Cancer Susceptibility in Purebred Dogs Purebred dogs are often at greater risk for specific cancers due to the limited genetic diversity within their breed lines. Selective breeding over generations has 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