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Over the years I have seen many dogs with anal sac cancer, and it is one of those tumors that always stays in the back of my mind. Not because it is rare, but because it is so easy to miss in the beginning. So many owners tell me the same thing afterward. Looking back, the signs were already there. They just did not think it could be cancer. In the beginning, the changes are usually very small. A dog may start taking longer to poop. They may squat for a long time and sometimes cry or strain. 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