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These tumors can vary in size, number, and malignancy. While spaying before the first heat cycle greatly reduces the risk, it&#8217;s still important for all dog owners to be aware of the signs and treatment options for this disease. Symptoms of mammary gland tumors in dogs may include lumps or masses in the mammary glands, which are located in the groin area. These masses may be firm, painless, and grow rapidly. In some cases, the skin over the mass may become ulcerated or inflamed. 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